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Association of diabetes and outcomes in patients with COVID-19: Propensity score-matched analyses from a French retrospective cohort.

Université de Paris, PARCC, INSERM, 75015 Paris, France. Université de Paris, PARCC, INSERM, 75015 Paris, France; Hôpital Européen Georges Pompidou, Université de Paris, 75015 Paris, France. Diabetology, Endocrinology and Nutrition Department, Bichat Hospital, APHP, Univeresité de Paris, Paris, France. Diabetology, Endocrinology and Nutrition Department, Bichat Hospital, APHP, Univeresité de Paris, Paris, France; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Immediab Team, F-75006 Paris, France. Nouvel Hôpital Civil, Centre Hospitalier Régional Universitaire de Strasbourg, 67000 Strasbourg, France. Centre Hospitalier Universitaire de Dijon, 21000 Dijon, France. Centre Hospitalier Régional Universitaire de Nancy, 54511 Vandoeuvre-Les-Nancy, France. Hôpital Européen Georges Pompidou, Université de Paris, 75015 Paris, France. Centre Hospitalier Universitaire d'Amiens-Picardie, 80000 Amiens, France. Centre Hospitalier Universitaire de Marseille, 13005 Marseille, France. GCS-Groupement des Hôpitaux de l'Institut Catholique de Lille, Faculté de Médecine et de Maïeutique, Université Catholique de Lille, Lille, France. Centre Hospitalier Universitaire de Toulouse, 31400 Toulouse, France. Centre Hospitalier Universitaire de Caen-Normandie, 14000 Caen, France. Centre Hospitalier Universitaire de Reims, 51100 Reims, France. Institut Mutualiste Montsouris, 75014 Paris, France. Institut Cardiovasculaire Paris Sud, 91300 Massy, France. Rouen University Hospital, FHU REMOD-VHF, F76000 Rouen, France. Université Paris-Saclay, INSERM, UMR-S 1180, 92296 Chatenay-Malabry, France. Hôpital Lariboisière, APHP, Université de Paris, 75010 Paris, France. Saint-Antoine Hospital, 75012 Paris, France. Diabetology, Endocrinology and Nutrition Department, Bichat Hospital, APHP, Univeresité de Paris, Paris, France; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Immediab Team, F-75006 Paris, France. Electronic address: louis.potier@gmail.com.

Diabetes & metabolism. 2021;(4):101222
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Abstract

BACKGROUND Our study aimed to compare the clinical outcomes of patients with and without diabetes admitted to hospital with COVID-19. METHODS This retrospective multicentre cohort study comprised 24 tertiary medical centres in France, and included 2851 patients (675 with diabetes) hospitalized for COVID-19 between 26 February and 20 April 2020. A propensity score-matching (PSM) method (1:1 matching including patients' characteristics, medical history, vital statistics and laboratory results) was used to compare patients with and without diabetes (n = 603 per group). The primary outcome was admission to an intensive care unit (ICU) and/or in-hospital death. RESULTS After PSM, all baseline characteristics were well balanced between those with and without diabetes: mean age was 71.2 years; 61.8% were male; and mean BMI was 29 kg/m2. A history of cardiovascular, chronic kidney and chronic obstructive pulmonary diseases were found in 32.8%, 22.1% and 6.4% of participants, respectively. The risk of experiencing the primary outcome was similar in patients with or without diabetes [hazard ratio (HR): 1.16, 95% confidence interval (CI): 0.95-1.41; P = 0.14], and was 1.29 (95% CI: 0.97-1.69) for in-hospital death, 1.26 (95% CI: 0.9-1.72) for death with no transfer to an ICU and 1.14 (95% CI: 0.88-1.47) with transfer to an ICU. CONCLUSION In this retrospective study cohort of patients hospitalized for COVID-19, diabetes was not significantly associated with a higher risk of severe outcomes after PSM. TRIAL REGISTRATION NUMBER NCT04344327.

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Publication Type : Observational Study

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